Structure of PDB 8be6 Chain S

Receptor sequence
>8be6S (length=440) Species: 9606 (Homo sapiens) [Search protein sequence]
LPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFV
RTFLTTYRSFCKPQELLSLIIERFEIPEPKRFRKEYIQPVQLRVLNVCRH
WVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIITF
QSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSEL
VGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSR
IIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEA
HELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKE
LINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKE
FTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN
3D structure
PDB8be6 Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
ChainS
Resolution2.8988 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide S Y884 F890 E902 H905 Y280 F286 E298 H301
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:8be6, PDBe:8be6, PDBj:8be6
PDBsum8be6
PubMed37067463
UniProtQ07889|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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