Structure of PDB 7e9g Chain S

Receptor sequence
>7e9gS (length=755) Species: 9606 (Homo sapiens) [Search protein sequence]
KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRI
NRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLTAITGVIGGSYS
DVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAM
AEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAM
SRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASD
GWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWF
REFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNM
HRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDR
FGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPL
PASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYW
PNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNAT
PVVKAAGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSV
CYSALLTKTNRISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPE
RREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFI
GFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAP
KLHII
3D structure
PDB7e9g Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4.
ChainS
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 40F S R57 R61 S143 Y144 S145 A166 S167 T168 Y216 K377 R35 R39 S98 Y99 S100 A121 S122 T123 Y171 K332 BindingDB: Ki=72nM,EC50=5.1nM,IC50=5.6nM
Gene Ontology
Molecular Function
GO:0001641 group II metabotropic glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0008066 glutamate receptor activity
GO:0097110 scaffold protein binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0010467 gene expression
GO:0014047 glutamate secretion
GO:0014048 regulation of glutamate secretion
GO:0014059 regulation of dopamine secretion
GO:0033554 cellular response to stress
GO:0035095 behavioral response to nicotine
GO:0042220 response to cocaine
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060292 long-term synaptic depression
GO:0090461 intracellular glutamate homeostasis
GO:0099171 presynaptic modulation of chemical synaptic transmission
GO:2001023 regulation of response to drug
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0042734 presynaptic membrane
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0097449 astrocyte projection
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e9g, PDBe:7e9g, PDBj:7e9g
PDBsum7e9g
PubMed34135510
UniProtQ14416|GRM2_HUMAN Metabotropic glutamate receptor 2 (Gene Name=GRM2)

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