Structure of PDB 6px3 Chain S

Receptor sequence
>6px3S (length=233) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
SSKLPPPQLFNEACRTFQVISDCLYGSRSSDHDALDCDCAEDWRDGKNHA
CGEDSDCINRATKIECVIGDCNCGEGCQNQRFQRKQYAKVSVIKTEKKGY
GLRADTDLQPNDFIYEYVGEVINEPTFRSRMLKYDKEGIKHFYFMSLTKN
EFVDATKKGNLGRFCNHSCNPNCYVDKWVVGDKLRMGIFAARYIKAGEEL
VFNYNVDRYGADPQPCYCGEPNCVGFIGGKTQT
3D structure
PDB6px3 Nucleosome and ubiquitin position Set2 to methylate H3K36.
ChainS
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN S C158 C163 C66 C71
BS02 ZN S C261 C308 C315 C169 C216 C223
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0046975 histone H3K36 methyltransferase activity
GO:0140955 histone H3K36 trimethyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome

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Cellular Component
External links
PDB RCSB:6px3, PDBe:6px3, PDBj:6px3
PDBsum6px3
PubMed31439846
UniProtG0S676

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