Structure of PDB 6la2 Chain S

Receptor sequence

>6la2S (length=75) Species: 9606 (Homo sapiens) [Search protein sequence]

TDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSI
KRLVTTGVLKQTKGVGASGSFRLAK

3D structure

PDB

6la2 Engineering nucleosomes for generating diverse chromatin assemblies.

Chain

Resolution

3.89 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	S	R47 K69 K73 A89 R94	R25 K47 K51 A67 R72
BS02	dna	S	K27 Y28 S46 Q48 S49 N63 R74	K5 Y6 S24 Q26 S27 N41 R52

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003680	minor groove of adenine-thymine-rich DNA binding
GO:0003690	double-stranded DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0030527	structural constituent of chromatin
GO:0031490	chromatin DNA binding
GO:0031491	nucleosome binding
GO:0031492	nucleosomal DNA binding

	Biological Process
GO:0006334	nucleosome assembly
GO:0030261	chromosome condensation
GO:0031507	heterochromatin formation
GO:0045910	negative regulation of DNA recombination
GO:2000679	positive regulation of transcription regulatory region DNA binding

	Cellular Component
GO:0000785	chromatin
GO:0000786	nucleosome
GO:0000791	euchromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005794	Golgi apparatus
GO:0015629	actin cytoskeleton
GO:0016604	nuclear body
GO:0017053	transcription repressor complex

External links