Structure of PDB 5jb8 Chain S

Receptor sequence
>5jb8S (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINTYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPL
VDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
3D structure
PDB5jb8 Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.
ChainS
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.22: coagulation factor IXa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA S E70 N72 E75 E77 E80 E55 N57 E60 E62 E65
BS02 0GJ S H57 Y99 D189 S190 C191 Q192 S195 S214 W215 G216 H41 Y86 D179 S180 C181 Q182 S185 S204 W205 G206
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5jb8, PDBe:5jb8, PDBj:5jb8
PDBsum5jb8
PubMed27208168
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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