Structure of PDB 5cdq Chain S

Receptor sequence
>5cdqS (length=193) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
LPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILN
VEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDG
AHIRTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMN
PEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYA
3D structure
PDB5cdq Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.
ChainS
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna S K460 L462 N463 K466 R471 N475 H515 V626 R629 K47 L49 N50 K53 R58 N62 H102 V179 R182
BS02 dna S P415 E435 D437 G459 K460 D512 P2 E22 D24 G46 K47 D99
BS03 MG S D508 D510 D95 D97
BS04 MFX S R458 G459 R45 G46
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5cdq, PDBe:5cdq, PDBj:5cdq
PDBsum5cdq
PubMed26640131
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB)

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