Structure of PDB 4urw Chain S

Receptor sequence
>4urwS (length=453) Species: 9606 (Homo sapiens) [Search protein sequence]
QMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTY
HMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYI
QPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVES
ITKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLE
SDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVET
ENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQ
IPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEE
GNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFE
NLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRP
SNP
3D structure
PDB4urw Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
ChainS
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DXO S M878 D887 F890 K898 L901 H905 M286 D295 F298 K306 L309 H313 PDBbind-CN: -logKd/Ki=2.80,Kd=1.6mM
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4urw, PDBe:4urw, PDBj:4urw
PDBsum4urw
PubMed25695162
UniProtQ07889|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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