Structure of PDB 4urv Chain S

Receptor sequence
>4urvS (length=450) Species: 9606 (Homo sapiens) [Search protein sequence]
RLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHM
YADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQP
VQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESIT
KIIQRKKIAQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDL
YRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENL
EERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPS
RQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNP
EVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLN
PMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP
3D structure
PDB4urv Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
ChainS
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMK S M878 N879 Y884 D887 F890 L901 M283 N284 Y289 D292 F295 L306 PDBbind-CN: -logKd/Ki=2.77,Kd=1.7mM
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4urv, PDBe:4urv, PDBj:4urv
PDBsum4urv
PubMed25695162
UniProtQ07889|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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