Structure of PDB 4uru Chain S

Receptor sequence
>4uruS (length=452) Species: 9606 (Homo sapiens) [Search protein sequence]
MRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYH
MYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQ
PVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESI
TKIIQRKKIAFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLES
DLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETE
NLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQI
PSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEG
NPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFEN
LNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPS
NP
3D structure
PDB4uru Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
ChainS
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6W2 S M878 N879 Y884 F890 L901 H905 M285 N286 Y291 F297 L308 H312 PDBbind-CN: -logKd/Ki=2.22,Kd=6.0mM
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4uru, PDBe:4uru, PDBj:4uru
PDBsum4uru
PubMed25695162
UniProtQ07889|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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