Structure of PDB 4p6z Chain S

Receptor sequence
>4p6zS (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]
MMRFMLLFSRRGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFL
EWRDLKVVYKRYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCE
LDIIFNFEKAYFILDEFLMGGDVQDTSKKSVLKAIEQADLLQEEDES
3D structure
PDB4p6z Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1.
ChainS
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide S R11 Y62 V98 C99 L101 R11 Y62 V98 C99 L101
Gene Ontology
Molecular Function
GO:0035615 clathrin adaptor activity
Biological Process
GO:0006886 intracellular protein transport
GO:0006898 receptor-mediated endocytosis
GO:0009615 response to virus
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0060155 platelet dense granule organization
GO:0110010 basolateral protein secretion
GO:1903232 melanosome assembly
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005905 clathrin-coated pit
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030121 AP-1 adaptor complex
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0032588 trans-Golgi network membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p6z, PDBe:4p6z, PDBj:4p6z
PDBsum4p6z
PubMed24843023
UniProtP61966|AP1S1_HUMAN AP-1 complex subunit sigma-1A (Gene Name=AP1S1)

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