Structure of PDB 2wpk Chain S

Receptor sequence
>2wpkS (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNFNAAINTYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPL
VDRATCLRSTKFTITNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
3D structure
PDB2wpk Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
ChainS
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.22: coagulation factor IXa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide S H57 Y99 F174 D189 S190 S195 S214 W215 G216 H41 Y86 F162 D179 S180 S185 S204 W205 G206
BS02 CA S E70 N72 E75 E77 E80 E55 N57 E60 E62 E65
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2wpk, PDBe:2wpk, PDBj:2wpk
PDBsum2wpk
PubMed20004170
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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