Structure of PDB 4lel Chain RP

Receptor sequence

>4lelRP (length=150) Species: 300852 (Thermus thermophilus HB8)

MKLSDLRPNPGANKRRKRVGRGPGSGHGKTATRGHKGQKSRSGGLKDPRR
FEGGRSTTLMRLPKRGMQGQVPGEIKRPRYQGVNLKDLARFEGEVTPELL
VRAGLLKKGYRLKILGEGEAKPLKVVAHAFSKSALEKLKAAGGEPVLLEA

3D structure

• PDB: 4lel Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops.
• Chain: RP
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	RP	L3 S4 R7 N9 G11 A12 N13 R15 K17 R18 R21 G22 P23 G24 S25 G28 K29 T30 T32 R33 G34 H35 K36 G37 Q38 K39 S40 R41 S42 K46 R50 F51 G53 G54 R55 S56 M60 R61 L62 P63 K64 R65 G66 M67 Q70 V71 P72 G73 E74 I75 K76 R77 G104 K107 K108 K113 L115 G116 E117 S131 K132 S133	L3 S4 R7 N9 G11 A12 N13 R15 K17 R18 R21 G22 P23 G24 S25 G28 K29 T30 T32 R33 G34 H35 K36 G37 Q38 K39 S40 R41 S42 K46 R50 F51 G53 G54 R55 S56 M60 R61 L62 P63 K64 R65 G66 M67 Q70 V71 P72 G73 E74 I75 K76 R77 G104 K107 K108 K113 L115 G116 E117 S131 K132 S133
BS02	MG	RP	E52 T58	E52 T58

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4lel, PDBe:4lel, PDBj:4lel
• PDBsum: 4lel
• PubMed: 25128388
• UniProt: Q5SHQ7|RL15_THET8 Large ribosomal subunit protein uL15 (Gene Name=rplO)