Structure of PDB 9iix Chain R

Receptor sequence
>9iixR (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTA
LAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLA
TGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINI
HINASINGYRRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQ
HTVKISGHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMG
MAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFK
3D structure
PDB9iix Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist.
ChainR
Resolution2.89 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AEI R G104 Y107 S194 F198 S232 V233 F236 Y240 G104 Y107 S181 F185 S213 V214 F217 Y221
BS02 A1AEI R I62 S65 F76 L85 W89 S265 Q266 I62 S65 F76 L85 W89 S246 Q247
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0008527 taste receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186 G protein-coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:9iix, PDBe:9iix, PDBj:9iix
PDBsum9iix
PubMed38969802
UniProtQ9NYV8|T2R14_HUMAN Taste receptor type 2 member 14 (Gene Name=TAS2R14)

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