Structure of PDB 9ayf Chain R

Receptor sequence

>9ayfR (length=816) Species: 9606 (Homo sapiens)

GPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRW
LQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEA
EERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLI
KEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGF
REFLKKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDENISSVETPYIDY
THLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVL
KHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYY
NVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTC
CFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEP
FGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCC
FSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIP
TSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEII
FITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSM
LIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIIL
FKPSRNTIEEVRCSTA

3D structure

• PDB: 9ayf Promiscuous G-protein activation by the calcium-sensing receptor
• Chain: R
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TCR	R	S147 A168 S170 Y218 E297	S117 A138 S140 Y188 E267
BS02	CA	R	I81 N82 S84 L87 L88	I61 N62 S64 L67 L68
BS03	CA	R	T100 A144 T145	T80 A114 T115
BS04	AV0	R	R795 A804 K805	R734 A743 K744
BS05	9IG	R	Q681 F684 I777 W818 Y825 E837	Q620 F623 I716 W757 Y764 E776

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:9ayf, PDBe:9ayf, PDBj:9ayf
• PDBsum: 9ayf
• PubMed: 38632411
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)