Structure of PDB 9avl Chain R

Receptor sequence

>9avlR (length=824) Species: 9606 (Homo sapiens)

GPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRW
LQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSN
KNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKF
REEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDL
EPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQ
IPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDENISSVETP
YIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEA
WQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKE
VGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEG
EPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLS
WTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFS
LLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFE
AKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELE
DEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFI
TFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKI
YIILFKPSRNTIEEVRCSTAAHAF

3D structure

• PDB: 9avl Promiscuous G-protein activation by the calcium-sensing receptor
• Chain: R
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TCR	R	S147 A168 S170 Y218 E297	S121 A142 S144 Y192 E271
BS02	CA	R	T100 N102 T145 V149	T80 N82 T119 V123
BS03	CA	R	R66 S302	R46 S276
BS04	9IG	R	Q681 F684 I777 W818 Y825 E837	Q624 F627 I720 W761 Y768 E780
BS05	A1AF7	R	F788 F792 R795 K805 T808 I816 I819	F731 F735 R738 K748 T751 I759 I762

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:9avl, PDBe:9avl, PDBj:9avl
• PDBsum: 9avl
• PubMed: 38632411
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)