Structure of PDB 9asb Chain R

Receptor sequence

>9asbR (length=809) Species: 9606 (Homo sapiens)

GPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRW
LQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNK
NQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFR
EEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLE
PLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQI
PGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDENISSVETPY
IDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAW
QVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEV
GYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGE
PTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSW
TEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSL
LCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEA
KIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELED
EIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFIT
FSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIY
IILFKPSRN

3D structure

• PDB: 9asb Promiscuous G-protein activation by the calcium-sensing receptor
• Chain: R
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TCR	R	R66 W70 S147 A168 S170 Y218 E297 A298	R46 W50 S120 A141 S143 Y191 E270 A271
BS02	CA	R	P39 T100 N102 T145	P19 T80 N82 T118
BS03	CA	R	R66 S302 S303	R46 S275 S276
BS04	9IG	R	Q681 F684 I777 W818 I822 Y825 E837	Q623 F626 I719 W760 I764 Y767 E779
BS05	A1AF7	R	F788 F792 R795 N802 A804 K805 T808 L812 I816 I819 S820	F730 F734 R737 N744 A746 K747 T750 L754 I758 I761 S762

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:9asb, PDBe:9asb, PDBj:9asb
• PDBsum: 9asb
• PubMed: 38632411
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)