Structure of PDB 8yuu Chain R

Receptor sequence
>8yuuR (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
AWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDF
LVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYD
RFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGS
SIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRL
RLDGSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHC
VPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL
3D structure
PDB8yuu Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
ChainR
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HSM R D114 Y115 C118 Y374 F398 W402 D83 Y84 C87 Y236 F260 W264
BS02 CLR R L40 M41 L44 E395 T396 W399 L9 M10 L13 E257 T258 W261
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0016907 G protein-coupled acetylcholine receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0098664 G protein-coupled serotonin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0045202 synapse
GO:0098793 presynapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8yuu, PDBe:8yuu, PDBj:8yuu
PDBsum8yuu
PubMed38647423
UniProtQ9Y5N1|HRH3_HUMAN Histamine H3 receptor (Gene Name=HRH3)

[Back to BioLiP]