Structure of PDB 8yky Chain R

Receptor sequence
>8ykyR (length=270) Species: 1502,9606 [Search protein sequence]
GVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALA
ISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATG
LGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHI
NASINRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKG
VKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCV
LILGNKKLRQASLSVLLWLR
3D structure
PDB8yky Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
ChainR
Resolution2.99 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AEI R G104 Y107 F198 L201 V230 V233 F237 H276 G102 Y105 F180 L183 V201 V204 F208 H247
BS02 CLR R F76 F82 L85 T86 W89 V180 S183 T184 I187 I262 S265 Q266 M268 F74 F80 L83 T84 W87 V162 S165 T166 I169 I233 S236 Q237 M239
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0008527 taste receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186 G protein-coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8yky, PDBe:8yky, PDBj:8yky
PDBsum8yky
PubMed38776963
UniProtQ59310;
Q9NYV8|T2R14_HUMAN Taste receptor type 2 member 14 (Gene Name=TAS2R14)

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