Structure of PDB 8xvh Chain R

Receptor sequence
>8xvhR (length=305) Species: 1502,9606 [Search protein sequence]
PPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGP
NILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVG
ITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPE
AIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPL
AITAFFYTLMTCEMLRLNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRI
LKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFK
NCFKS
3D structure
PDB8xvh Structural basis of antagonist selectivity in endothelin receptors.
ChainR
Resolution3.26 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R P87 N158 K161 E165 W167 Q181 M245 D246 Y247 K248 I254 L256 L257 P259 R343 R357 L361 L365 D368 P1 N72 K75 E79 W81 Q95 M159 D160 Y161 K162 I168 L170 L171 P173 R249 R263 L267 L271 D274
External links
PDB RCSB:8xvh, PDBe:8xvh, PDBj:8xvh
PDBsum8xvh
PubMed39075075
UniProtP24530|EDNRB_HUMAN Endothelin receptor type B (Gene Name=EDNRB);
Q59310

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