Structure of PDB 8xqs Chain R

Receptor sequence
>8xqsR (length=271) Species: 1502,9606 [Search protein sequence]
GGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTAL
AISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLAT
GLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIH
INASINGFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQH
TVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSC
VLILGNKKLRQASLSVLLWLR
3D structure
PDB8xqs Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
ChainR
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLF R G104 Y107 S194 F198 F237 H276 G103 Y106 S180 F184 F209 H248
BS02 CLR R I62 S65 F76 F82 L85 W89 F172 V180 T184 I187 S265 M268 G269 I61 S64 F75 F81 L84 W88 F158 V166 T170 I173 S237 M240 G241
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0008527 taste receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186 G protein-coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8xqs, PDBe:8xqs, PDBj:8xqs
PDBsum8xqs
PubMed38776963
UniProtQ59310;
Q9NYV8|T2R14_HUMAN Taste receptor type 2 member 14 (Gene Name=TAS2R14)

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