Structure of PDB 8xqo Chain R

Receptor sequence
>8xqoR (length=281) Species: 1502,9606 [Search protein sequence]
GGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTAL
AISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLAT
GLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIH
INASINGYRRNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRK
KMQHTVKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVM
GMAYPSCHSCVLILGNKKLRQASLSVLLWLR
3D structure
PDB8xqo Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
ChainR
Resolution2.77 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOQ R G104 Y107 S194 F198 L201 G229 V233 F237 H276 G103 Y106 S184 F188 L191 G211 V215 F219 H258
BS02 CLR R F82 W89 V180 T184 I187 F247 I262 S265 M268 F81 W88 V170 T174 I177 F229 I244 S247 M250
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0008527 taste receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186 G protein-coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8xqo, PDBe:8xqo, PDBj:8xqo
PDBsum8xqo
PubMed38776963
UniProtQ59310;
Q9NYV8|T2R14_HUMAN Taste receptor type 2 member 14 (Gene Name=TAS2R14)

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