Structure of PDB 8xqn Chain R

Receptor sequence
>8xqnR (length=284) Species: 1502,9606 [Search protein sequence]
GGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTAL
AISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLAT
GLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIH
INASINGYRFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKM
QHTVKDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILS
QVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLR
3D structure
PDB8xqn Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
ChainR
Resolution3.05 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOQ R G104 Y107 S194 M197 F198 L201 V233 F237 H276 G103 Y106 S182 M185 F186 L189 V218 F222 H261
BS02 CLR R S65 F76 M81 F82 L85 W89 F172 V180 S183 T184 I187 S265 M268 S64 F75 M80 F81 L84 W88 F160 V168 S171 T172 I175 S250 M253
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0008527 taste receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186 G protein-coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8xqn, PDBe:8xqn, PDBj:8xqn
PDBsum8xqn
PubMed38776963
UniProtQ59310;
Q9NYV8|T2R14_HUMAN Taste receptor type 2 member 14 (Gene Name=TAS2R14)

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