Structure of PDB 8xql Chain R

Receptor sequence
>8xqlR (length=285) Species: 1502,9606 [Search protein sequence]
GGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTAL
AISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLAT
GLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIH
INASINGFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQH
TVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIIL
SQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLR
3D structure
PDB8xql Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
ChainR
Resolution2.99 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOQ R G104 Y107 S194 F198 L201 G229 V233 F237 H276 G103 Y106 S180 F184 L187 G215 V219 F223 H262
BS02 GOQ R I111 L201 S204 M205 H208 A226 I110 L187 S190 M191 H194 A212
BS03 CLR R F76 F82 W89 V180 T184 I187 F247 M268 G269 F75 F81 W88 V166 T170 I173 F233 M254 G255
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0008527 taste receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186 G protein-coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8xql, PDBe:8xql, PDBj:8xql
PDBsum8xql
PubMed38776963
UniProtQ59310;
Q9NYV8|T2R14_HUMAN Taste receptor type 2 member 14 (Gene Name=TAS2R14)

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