Structure of PDB 8xgr Chain R
Receptor sequence
>8xgrR (length=305) Species:
9606
(Homo sapiens) [
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SPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNG
PNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASV
GITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVP
EAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLP
LAITAFFYTLMTCEMLLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLT
LYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFK
SCLCC
3D structure
PDB
8xgr
Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application.
Chain
R
Resolution
3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
peptide
R
S86 P87 N158 K161 E165 W167 Q181 K182 M245 D246 Y247 L252 I254 L257 P259 K273 L339 R343 K346 Y350 C358 L361 L365 D368 Y369 I372
S1 P2 N73 K76 E80 W82 Q96 K97 M160 D161 Y162 L167 I169 L172 P174 K188 L241 R245 K248 Y252 C260 L263 L267 D270 Y271 I274
Gene Ontology
Molecular Function
GO:0004930
G protein-coupled receptor activity
GO:0004962
endothelin receptor activity
GO:0005515
protein binding
GO:0017046
peptide hormone binding
GO:0031702
type 1 angiotensin receptor binding
Biological Process
GO:0000122
negative regulation of transcription by RNA polymerase II
GO:0001755
neural crest cell migration
GO:0002001
renin secretion into blood stream
GO:0002027
regulation of heart rate
GO:0006885
regulation of pH
GO:0007166
cell surface receptor signaling pathway
GO:0007186
G protein-coupled receptor signaling pathway
GO:0007194
negative regulation of adenylate cyclase activity
GO:0007200
phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204
positive regulation of cytosolic calcium ion concentration
GO:0007399
nervous system development
GO:0007422
peripheral nervous system development
GO:0007497
posterior midgut development
GO:0008015
blood circulation
GO:0008217
regulation of blood pressure
GO:0008284
positive regulation of cell population proliferation
GO:0010467
gene expression
GO:0014043
negative regulation of neuron maturation
GO:0014070
response to organic cyclic compound
GO:0014826
vein smooth muscle contraction
GO:0019722
calcium-mediated signaling
GO:0019934
cGMP-mediated signaling
GO:0030202
heparin metabolic process
GO:0030318
melanocyte differentiation
GO:0031620
regulation of fever generation
GO:0032341
aldosterone metabolic process
GO:0032496
response to lipopolysaccharide
GO:0035645
enteric smooth muscle cell differentiation
GO:0035810
positive regulation of urine volume
GO:0035812
renal sodium excretion
GO:0042045
epithelial fluid transport
GO:0042310
vasoconstriction
GO:0042311
vasodilation
GO:0043066
negative regulation of apoptotic process
GO:0043123
positive regulation of canonical NF-kappaB signal transduction
GO:0043473
pigmentation
GO:0048066
developmental pigmentation
GO:0048246
macrophage chemotaxis
GO:0048265
response to pain
GO:0048484
enteric nervous system development
GO:0050678
regulation of epithelial cell proliferation
GO:0051248
negative regulation of protein metabolic process
GO:0055078
sodium ion homeostasis
GO:0060070
canonical Wnt signaling pathway
GO:0060406
positive regulation of penile erection
GO:0061028
establishment of endothelial barrier
GO:0065008
regulation of biological quality
GO:0070294
renal sodium ion absorption
GO:0070588
calcium ion transmembrane transport
GO:0071222
cellular response to lipopolysaccharide
GO:0071806
protein transmembrane transport
GO:0072112
podocyte differentiation
GO:0086100
endothelin receptor signaling pathway
GO:0097018
renal albumin absorption
GO:0097402
neuroblast migration
GO:0160093
chordate pharynx development
GO:1904383
response to sodium phosphate
GO:1990839
response to endothelin
Cellular Component
GO:0005886
plasma membrane
GO:0016020
membrane
GO:0031965
nuclear membrane
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:8xgr
,
PDBe:8xgr
,
PDBj:8xgr
PDBsum
8xgr
PubMed
38128244
UniProt
P24530
|EDNRB_HUMAN Endothelin receptor type B (Gene Name=EDNRB)
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