Structure of PDB 8xgr Chain R

Receptor sequence
>8xgrR (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
SPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNG
PNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASV
GITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVP
EAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLP
LAITAFFYTLMTCEMLLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLT
LYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFK
SCLCC
3D structure
PDB8xgr Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application.
ChainR
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004962 endothelin receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0031702 type 1 angiotensin receptor binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001755 neural crest cell migration
GO:0002001 renin secretion into blood stream
GO:0002027 regulation of heart rate
GO:0006885 regulation of pH
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007399 nervous system development
GO:0007422 peripheral nervous system development
GO:0007497 posterior midgut development
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell population proliferation
GO:0010467 gene expression
GO:0014043 negative regulation of neuron maturation
GO:0014070 response to organic cyclic compound
GO:0014826 vein smooth muscle contraction
GO:0019722 calcium-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0030202 heparin metabolic process
GO:0030318 melanocyte differentiation
GO:0031620 regulation of fever generation
GO:0032341 aldosterone metabolic process
GO:0032496 response to lipopolysaccharide
GO:0035645 enteric smooth muscle cell differentiation
GO:0035810 positive regulation of urine volume
GO:0035812 renal sodium excretion
GO:0042045 epithelial fluid transport
GO:0042310 vasoconstriction
GO:0042311 vasodilation
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0043473 pigmentation
GO:0048066 developmental pigmentation
GO:0048246 macrophage chemotaxis
GO:0048265 response to pain
GO:0048484 enteric nervous system development
GO:0050678 regulation of epithelial cell proliferation
GO:0051248 negative regulation of protein metabolic process
GO:0055078 sodium ion homeostasis
GO:0060070 canonical Wnt signaling pathway
GO:0060406 positive regulation of penile erection
GO:0061028 establishment of endothelial barrier
GO:0065008 regulation of biological quality
GO:0070294 renal sodium ion absorption
GO:0070588 calcium ion transmembrane transport
GO:0071222 cellular response to lipopolysaccharide
GO:0071806 protein transmembrane transport
GO:0072112 podocyte differentiation
GO:0086100 endothelin receptor signaling pathway
GO:0097018 renal albumin absorption
GO:0097402 neuroblast migration
GO:0160093 chordate pharynx development
GO:1904383 response to sodium phosphate
GO:1990839 response to endothelin
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031965 nuclear membrane

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8xgr, PDBe:8xgr, PDBj:8xgr
PDBsum8xgr
PubMed38128244
UniProtP24530|EDNRB_HUMAN Endothelin receptor type B (Gene Name=EDNRB)

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