Structure of PDB 8x17 Chain R

Receptor sequence
>8x17R (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLAL
ADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAV
DRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSE
YHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRN
KLSLGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGI
LLSHANSMMNPIVYAYKIKKFKETYLLILKAC
3D structure
PDB8x17 Cryo-EM structures of adenosine receptor A3AR bound to selective agonists
ChainR
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XS0 R T94 H95 Q167 F168 V169 M177 N250 L264 I268 H272 T88 H89 Q161 F162 V163 M171 N232 L246 I250 H254
Gene Ontology
Molecular Function
GO:0001609 G protein-coupled adenosine receptor activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0001973 G protein-coupled adenosine receptor signaling pathway
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0008016 regulation of heart contraction
GO:0008285 negative regulation of cell population proliferation
GO:0009611 response to wounding
GO:0014061 regulation of norepinephrine secretion
GO:0030336 negative regulation of cell migration
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0099171 presynaptic modulation of chemical synaptic transmission
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0042734 presynaptic membrane
GO:0045202 synapse
GO:0098685 Schaffer collateral - CA1 synapse

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Cellular Component
External links
PDB RCSB:8x17, PDBe:8x17, PDBj:8x17
PDBsum8x17
PubMed38627384
UniProtP0DMS8|AA3R_HUMAN Adenosine receptor A3 (Gene Name=ADORA3)

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