Structure of PDB 8wz2 Chain R

Receptor sequence
>8wz2R (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
EQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFAL
ALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNIS
DNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYT
NRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSP
VHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKMSKIARKKKRAVIM
MVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSN
SICNPIVYAFMNENFKKNVLSA
3D structure
PDB8wz2 Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor.
ChainR
Resolution2.73 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R E9 V35 C98 V101 L104 Q105 S108 N110 W111 C118 P122 Q125 C200 C201 L202 E203 Y214 F289 H293 Q318 F322 E1 V27 C90 V93 L96 Q97 S100 N102 W103 C110 P114 Q117 C192 C193 L194 E195 Y206 F265 H269 Q294 F298
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005515 protein binding
GO:0042277 peptide binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0032870 cellular response to hormone stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8wz2, PDBe:8wz2, PDBj:8wz2
PDBsum8wz2
PubMed38830850
UniProtQ96P65|QRFPR_HUMAN Pyroglutamylated RF-amide peptide receptor (Gene Name=QRFPR)

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