Structure of PDB 8wc7 Chain R

Receptor sequence
>8wc7R (length=270) Species: 10090 (Mus musculus) [Search protein sequence]
LYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCL
IMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAV
CDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQ
VSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSIN
RTTKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGY
LNSALNPMVYAFFYPWFRRA
3D structure
PDB8wc7 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
ChainR
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VMK R D102 I103 Y153 A193 S197 F264 F265 Y287 Y291 D78 I79 Y129 A169 S173 F223 F224 Y246 Y250
Gene Ontology
Molecular Function
GO:0001594 trace-amine receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0008227 G protein-coupled amine receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8wc7, PDBe:8wc7, PDBj:8wc7
PDBsum8wc7
PubMed37963465
UniProtQ923Y8|TAAR1_MOUSE Trace amine-associated receptor 1 (Gene Name=Taar1)

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