Structure of PDB 8thk Chain R

Receptor sequence
>8thkR (length=244) Species: 9606,10665 [Search protein sequence]
LGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPF
SAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPL
RYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEP
GYVLFSALGSFYLPLAIILVMYCRVYVVAKRESKKAAKTLGIVVGCFVLC
WLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPC
3D structure
PDB8thk Structural basis of agonist specificity of alpha 1A-adrenergic receptor
ChainR
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CGZ R D106 V107 C110 V185 S188 W285 F288 F289 F312 Y316 D74 V75 C78 V153 S156 W201 F204 F205 F228 Y232
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Cellular Component
External links
PDB RCSB:8thk, PDBe:8thk, PDBj:8thk
PDBsum8thk
PubMed37563160
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P35348

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