Structure of PDB 8t3v Chain R

Receptor sequence
>8t3vR (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGC
SDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAAL
SAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGW
LDHSNTSLGINTPVNVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYV
GCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNL
GGSWRKLGLITGAWSVVLNPLVTGYL
3D structure
PDB8t3v Structural basis for the ligand recognition and signaling of free fatty acid receptors.
ChainR
Resolution3.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HXA R A83 V84 F87 L135 L138 F142 R183 R258 A83 V84 F87 L135 L138 F142 R180 R255
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0008289 lipid binding
GO:0045125 bioactive lipid receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0030073 insulin secretion
GO:0032024 positive regulation of insulin secretion
GO:0032691 negative regulation of interleukin-1 beta production
GO:0042593 glucose homeostasis
GO:0051928 positive regulation of calcium ion transport
GO:0070542 response to fatty acid
GO:0099105 ion channel modulating, G protein-coupled receptor signaling pathway
GO:1990806 ligand-gated ion channel signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t3v, PDBe:8t3v, PDBj:8t3v
PDBsum8t3v
PubMed38198545
UniProtO14842|FFAR1_HUMAN Free fatty acid receptor 1 (Gene Name=FFAR1)

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