Structure of PDB 8kae Chain R

Receptor sequence
>8kaeR (length=417) Species: 9606 (Homo sapiens) [Search protein sequence]
GRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFIC
SFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLS
RGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITG
SSVKQAAGDWHWALRVSPVLGMITGTLILILVPATSWLRDMKALIRNRSY
VFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAAKDSLIFGAITCFTG
FLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVG
AYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAG
SPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATAL
FFVSDRARAEQQVNQLA
3D structure
PDB8kae Structural basis of Sphingosine-1-phosphate transport via human SPNS2.
ChainR
Resolution3.18 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YUX R Y116 T329 L332 I336 E433 Y17 T214 L217 I221 E309
Gene Ontology
Molecular Function
GO:0022857 transmembrane transporter activity
GO:0046624 sphingolipid transporter activity
Biological Process
GO:0001782 B cell homeostasis
GO:0002260 lymphocyte homeostasis
GO:0002920 regulation of humoral immune response
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0006665 sphingolipid metabolic process
GO:0006869 lipid transport
GO:0007605 sensory perception of sound
GO:0030148 sphingolipid biosynthetic process
GO:0043029 T cell homeostasis
GO:0048073 regulation of eye pigmentation
GO:0048535 lymph node development
GO:0055085 transmembrane transport
GO:0060348 bone development
GO:0072676 lymphocyte migration
GO:2000404 regulation of T cell migration
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8kae, PDBe:8kae, PDBj:8kae
PDBsum8kae
PubMed38123825
UniProtQ8IVW8|SPNS2_HUMAN Sphingosine-1-phosphate transporter SPNS2 (Gene Name=SPNS2)

[Back to BioLiP]