Structure of PDB 8k2w Chain R

Receptor sequence
>8k2wR (length=285) Species: 562,9606 [Search protein sequence]
AFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLV
LTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI
VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHC
QYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILARLKSVRLLSGSRE
KDRNLRRITRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESR
VDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMW
3D structure
PDB8k2w Structure basis for the modulation of CXC chemokine receptor 3 by antagonist AMG487
ChainR
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR R H94 L130 W176 H41 L77 W123
BS02 LPC R C144 L159 Y160 L170 C91 L106 Y107 L117
BS03 FI6 R Y60 W109 K308 S309 S312 Y316 Y7 W56 K255 S256 S259 Y263
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0016494 C-X-C chemokine receptor activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0002685 regulation of leukocyte migration
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Biological Process
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Cellular Component
External links
PDB RCSB:8k2w, PDBe:8k2w, PDBj:8k2w
PDBsum8k2w
PubMed38012179
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P41145|OPRK_HUMAN Kappa-type opioid receptor (Gene Name=OPRK1);
P49682

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