Structure of PDB 8jgg Chain R

Receptor sequence
>8jggR (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLFLS
GRLIYSLLKILYPVMMFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTH
LSAVVCVLLWALSLLRSILEWMWCQTSDFITVAWLIFLCVVLCGSSLVLL
IRILCGSRTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHV
HLVSIFLSALNSSANPIIYFFVG
3D structure
PDB8jgg Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
ChainR
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R Y99 E157 W158 F237 L240 W241 H243 L249 F250 H254 Y62 E120 W121 F184 L187 W188 H190 L196 F197 H201
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:1902349 response to chloroquine
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jgg, PDBe:8jgg, PDBj:8jgg
PDBsum8jgg
PubMed37591889
UniProtQ96LB2|MRGX1_HUMAN Mas-related G-protein coupled receptor member X1 (Gene Name=MRGPRX1)

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