Structure of PDB 8j6q Chain R

Receptor sequence
>8j6qR (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
DHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLK
SWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFML
AMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIG
LTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFC
SARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWL
LHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFN
3D structure
PDB8j6q Orthosteric and allosteric modulation of human HCAR2 signaling complex.
ChainR
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IX8 R C183 H184 T185 F186 Q187 A191 L195 F255 L258 C176 H177 T178 F179 Q180 A184 L188 F248 L251
BS02 CLR R I64 F67 N68 A145 W152 I57 F60 N61 A138 W145
BS03 3HR R R111 S178 S179 F180 Y284 R104 S171 S172 F173 Y277
BS04 CLR R Q112 I116 T119 V120 V123 L151 L195 Q105 I109 T112 V113 V116 L144 L188
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8j6q, PDBe:8j6q, PDBj:8j6q
PDBsum8j6q
PubMed37993467
UniProtQ8TDS4|HCAR2_HUMAN Hydroxycarboxylic acid receptor 2 (Gene Name=HCAR2)

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