BioLiP

>8iy5R (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]

PPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPN
ILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGI
TVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEA
IGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLA
ITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWL
PLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALY
LVSKRFKNCFKSCLCC

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

peptide

P88 I94 I157 N158 K161 E165 Q181 M245 Y247 I254 L256 P259 L277 L339 R343 K346 Y350 Q352 R357 L361 L365 D368 Y369

P1 I7 I70 N71 K74 E78 Q94 M158 Y160 I167 L169 P172 L190 L252 R256 K259 Y263 Q265 R270 L274 L278 D281 Y282

Molecular Function

GO:0004930

G protein-coupled receptor activity

GO:0004962

endothelin receptor activity

GO:0005515

protein binding

GO:0017046

peptide hormone binding

GO:0031702

type 1 angiotensin receptor binding

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0001755	neural crest cell migration
GO:0002001	renin secretion into blood stream
GO:0002027	regulation of heart rate
GO:0006885	regulation of pH
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007399	nervous system development
GO:0007422	peripheral nervous system development
GO:0007497	posterior midgut development
GO:0008015	blood circulation
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell population proliferation
GO:0010467	gene expression
GO:0014043	negative regulation of neuron maturation
GO:0014070	response to organic cyclic compound
GO:0014826	vein smooth muscle contraction
GO:0019722	calcium-mediated signaling
GO:0019934	cGMP-mediated signaling
GO:0030202	heparin metabolic process
GO:0030318	melanocyte differentiation
GO:0031620	regulation of fever generation
GO:0032341	aldosterone metabolic process
GO:0032496	response to lipopolysaccharide
GO:0035645	enteric smooth muscle cell differentiation
GO:0035810	positive regulation of urine volume
GO:0035812	renal sodium excretion
GO:0042045	epithelial fluid transport
GO:0042310	vasoconstriction
GO:0042311	vasodilation
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of canonical NF-kappaB signal transduction
GO:0043473	pigmentation
GO:0048066	developmental pigmentation
GO:0048246	macrophage chemotaxis
GO:0048265	response to pain
GO:0048484	enteric nervous system development
GO:0050678	regulation of epithelial cell proliferation
GO:0051248	negative regulation of protein metabolic process
GO:0055078	sodium ion homeostasis
GO:0060070	canonical Wnt signaling pathway
GO:0060406	positive regulation of penile erection
GO:0061028	establishment of endothelial barrier
GO:0065008	regulation of biological quality
GO:0070294	renal sodium ion absorption
GO:0070588	calcium ion transmembrane transport
GO:0071222	cellular response to lipopolysaccharide
GO:0071806	protein transmembrane transport
GO:0072112	podocyte differentiation
GO:0086100	endothelin receptor signaling pathway
GO:0097018	renal albumin absorption
GO:0097402	neuroblast migration
GO:0160093	chordate pharynx development
GO:1904383	response to sodium phosphate
GO:1990839	response to endothelin

Biological Process

GO:0000122

negative regulation of transcription by RNA polymerase II

GO:0001755

neural crest cell migration

GO:0002001

renin secretion into blood stream

GO:0002027

regulation of heart rate

GO:0006885

regulation of pH

GO:0007166