Structure of PDB 8iuk Chain R

Receptor sequence
>8iukR (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
SVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDF
FGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSV
MAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYK
IQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLL
RVKFKSQQHGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSL
ETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCC
3D structure
PDB8iuk Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor.
ChainR
Resolution2.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UGU R F32 S33 H81 N84 G85 R291 T294 F4 S5 H53 N56 G57 R261 T264
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004958 prostaglandin F receptor activity
Biological Process
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007567 parturition
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0043066 negative regulation of apoptotic process
GO:0071799 cellular response to prostaglandin D stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iuk, PDBe:8iuk, PDBj:8iuk
PDBsum8iuk
PubMed37160891
UniProtP43088|PF2R_HUMAN Prostaglandin F2-alpha receptor (Gene Name=PTGFR)

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