Structure of PDB 8iq6 Chain R

Receptor sequence
>8iq6R (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
RLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVIT
DFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLG
SVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRD
YKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGIT
LLRHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFA
LRMATWNQILDPWVYILLRKAVLK
3D structure
PDB8iq6 Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity.
ChainR
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7WT R S33 F36 H81 Y92 F111 M115 G119 T184 F265 L290 T294 S7 F10 H55 Y66 F85 M89 G93 T158 F226 L251 T255
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004958 prostaglandin F receptor activity
Biological Process
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007567 parturition
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0043066 negative regulation of apoptotic process
GO:0071799 cellular response to prostaglandin D stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8iq6, PDBe:8iq6, PDBj:8iq6
PDBsum8iq6
PubMed38065938
UniProtP43088|PF2R_HUMAN Prostaglandin F2-alpha receptor (Gene Name=PTGFR)

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