Structure of PDB 8ipx Chain R

Receptor sequence

>8ipxR (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]

GFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRM
IVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCT
GLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLA
RTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMG
QNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENP
VYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERA

3D structure

PDB

8ipx Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.

Chain

Resolution

4.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	R	F3 Y12 R15 Y16 Q17 K19 R23 G26 Y31 R35 L36 N42 K43 Y44 N45 T46 K48 Y49 Y145 L146 A148 R152 T153 F160 K178 R179 R265 R268 S272 Q275 D278 Q282 K283 F287 R289	F2 Y11 R14 Y15 Q16 K18 R22 G25 Y30 R34 L35 N41 K42 Y43 N44 T45 K47 Y48 Y144 L145 A147 R151 T152 F159 K177 R178 R264 R267 S271 Q274 D277 Q281 K282 F286 R288
BS02	rna	R	K8 K10 F13 K14 V18 F20 R21 R22 R24 K27 T28 R33 R50 R54 T56 N57 R58 D59 I69 E70 D72 M73 I74 Y79 N94 R152 T154 T155 N157 H198 Y207 Q222 Q225 Y226 Y253 K255 K256 K258 E260 K263 W266 R268 K270 L273	K7 K9 F12 K13 V17 F19 R20 R21 R23 K26 T27 R32 R49 R53 T55 N56 R57 D58 I68 E69 D71 M72 I73 Y78 N93 R151 T153 T154 N156 H197 Y206 Q221 Q224 Y225 Y252 K254 K255 K257 E259 K262 W265 R267 K269 L272

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0048027	mRNA 5'-UTR binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0010628	positive regulation of gene expression
GO:0042273	ribosomal large subunit biogenesis
GO:0045727	positive regulation of translation
GO:0050821	protein stabilization
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8ipx, PDBe:8ipx, PDBj:8ipx
PDBsum	8ipx
PubMed	37491604
UniProt	P46777\|RL5_HUMAN Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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