Structure of PDB 8inr Chain R

Receptor sequence
>8inrR (length=271) Species: 9606,392809 [Search protein sequence]
IAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSM
SSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIA
VDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVI
LCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASRTSMQGAVTVT
MLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMD
PLIYAFRSQEMRKTFKEIICC
3D structure
PDB8inr Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.
ChainR
Resolution2.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R E92 I96 R112 D115 N116 D119 I122 C123 I178 S181 I187 M261 F277 N278 E55 I59 R75 D78 N79 D82 I85 C86 I141 S144 I150 M220 F236 N237
BS02 CA R E92 D115 D119 E55 D78 D82
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0005515 protein binding
GO:0042562 hormone binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0019222 regulation of metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8inr, PDBe:8inr, PDBj:8inr
PDBsum8inr
PubMed37524700
UniProtP03435;
P33032

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