Structure of PDB 8hcq Chain R

Receptor sequence
>8hcqR (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
HNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGP
NALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQ
KSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFI
LAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFC
MPLVCTAIFYTLMTCEMLNLSEHLKQRREVAKTVFCLVVIFALCWFPLHL
SRILKKTVYEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKK
FKN
3D structure
PDB8hcq Structural basis of peptide recognition and activation of endothelin receptors.
ChainR
Resolution3.01 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.13.12.13: Oplophorus-luciferin 2-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R Q72 N137 K140 G144 Q165 K166 Y231 T238 Q252 L259 W319 R326 M336 L344 L348 D351 Q7 N72 K75 G79 Q100 K101 Y166 T173 Q187 L194 W245 R252 M261 L269 L273 D276
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004962 endothelin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0042310 vasoconstriction
GO:0048484 enteric nervous system development
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hcq, PDBe:8hcq, PDBj:8hcq
PDBsum8hcq
PubMed36882417
UniProtP25101|EDNRA_HUMAN Endothelin-1 receptor (Gene Name=EDNRA)

[Back to BioLiP]