Structure of PDB 8haf Chain R

Receptor sequence
>8hafR (length=369) Species: 9606 (Homo sapiens) [Search protein sequence]
VMTKEEQIFLLHRAQAQCEKRLKEVGRPCLPEWDHILCWPLGAPGEVVAV
PCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETR
EREVFDRLAMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLS
FMLRAVSIFVKDAVLYSGAGYAGCRVAVTFFLYFLATNYYWILVEGLYLH
SLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSG
NKKWIIQVPILASIVLNFILFINIVRVLATKLRETNTRQQYRKLLKSTLV
LMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFC
NGEVQAEIKKSWSRWTLAL
3D structure
PDB8haf Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1.
ChainR
Resolution3.25 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR R L411 M414 P415 H420 F454 I458 L299 M302 P303 H308 F342 I346
BS02 CLR R V243 G280 V164 G173
BS03 CLR R V204 Y211 S473 V125 Y132 S361
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004991 parathyroid hormone receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8haf, PDBe:8haf, PDBj:8haf
PDBsum8haf
PubMed36482086
UniProtQ03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)

[Back to BioLiP]