Structure of PDB 8ha0 Chain R

Receptor sequence
>8ha0R (length=359) Species: 9606 (Homo sapiens) [Search protein sequence]
VMTKEEQIFLLHRAQAQCEKGRPCLPEWDHILCWPLGAPGEVVAVPCPDY
IYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKETREREVFDRLA
MIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIF
VKDAVLYSAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSE
KKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPI
LASIVLNFILFINIVRVLATKLRETNTRQQYRKLLKSTLVLMPLFGVHYI
VFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKK
SWSRWTLAL
3D structure
PDB8ha0 Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1.
ChainR
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR R I362 V365 P366 I245 V248 P249
BS02 CLR R W361 L368 V372 A426 W244 L251 V255 A304
BS03 CLR R V382 R383 A386 L406 V265 R266 A269 L284
BS04 CLR R M189 I190 F450 M101 I102 F328
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004991 parathyroid hormone receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8ha0, PDBe:8ha0, PDBj:8ha0
PDBsum8ha0
PubMed36482086
UniProtQ03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)

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