Structure of PDB 8ggb Chain R

Receptor sequence
>8ggbR (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
VWVVGMGIVMSLIVLAIVFGNVLVITAIAQTVTNYFITSLACADLVMGLA
VVPFGAAHILTTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAIT
SPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYA
EETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKS
EHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYV
NSGFNPLIYCRSPDF
3D structure
PDB8ggb Time-resolved cryo-EM of G protein activation by a GPCR
ChainR
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G1I R F193 S203 F289 Y308 F157 S167 F222 Y241
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004941 beta2-adrenergic receptor activity
Biological Process
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0097746 blood vessel diameter maintenance
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ggb, PDBe:8ggb, PDBj:8ggb
PDBsum8ggb
PubMed38480881
UniProtP07550|ADRB2_HUMAN Beta-2 adrenergic receptor (Gene Name=ADRB2)

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