Structure of PDB 8geb Chain R

Receptor sequence
>8gebR (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
VWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADL
VMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVD
RYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQL
QKIDKSEGRHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYI
LLNWIGYVNSGFNPLIYCRSPDFRIAFQELL
3D structure
PDB8geb Time-resolved cryo-EM of G protein activation by a GPCR
ChainR
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G1I R D113 V117 F193 F289 F290 Y308 N312 Y316 D83 V87 F163 F230 F231 Y249 N253 Y257
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004941 beta2-adrenergic receptor activity
Biological Process
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0097746 blood vessel diameter maintenance
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8geb, PDBe:8geb, PDBj:8geb
PDBsum8geb
PubMed38480881
UniProtP07550|ADRB2_HUMAN Beta-2 adrenergic receptor (Gene Name=ADRB2)

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