Structure of PDB 8ejc Chain R

Receptor sequence
>8ejcR (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCS
DLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALS
AGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGTSL
GINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRA
LARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWR
KLGLITGAWSVVLNPLVTGYL
3D structure
PDB8ejc Molecular mechanism of fatty acid activation of FFAR1.
ChainR
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2YB R P80 F87 L138 V141 F142 L158 L171 R183 Y240 P79 F86 L137 V140 F141 L150 L163 R175 Y232
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0008289 lipid binding
GO:0045125 bioactive lipid receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0030073 insulin secretion
GO:0032024 positive regulation of insulin secretion
GO:0032691 negative regulation of interleukin-1 beta production
GO:0042593 glucose homeostasis
GO:0051928 positive regulation of calcium ion transport
GO:0070542 response to fatty acid
GO:0099105 ion channel modulating, G protein-coupled receptor signaling pathway
GO:1990806 ligand-gated ion channel signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8ejc, PDBe:8ejc, PDBj:8ejc
PDBsum8ejc
PubMed37216523
UniProtO14842|FFAR1_HUMAN Free fatty acid receptor 1 (Gene Name=FFAR1)

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