Structure of PDB 8efl Chain R

Receptor sequence

>8eflR (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]

SMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALA
DALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSV
DRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQG
SIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVR
MLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTF
QTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREF

3D structure

PDB

8efl Molecular recognition of morphine and fentanyl by the human mu-opioid receptor.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	WH9	R	Q126 W135 D149 Y150 M153 C219 I298	Q61 W70 D84 Y85 M88 C154 I233
BS02	CLR	R	L114 Y151 K187 W194	L49 Y86 K122 W129
BS03	CLR	R	P297 Y301 S319	P232 Y236 S254
BS04	CLR	R	I200 M207 W230 C237 F241	I135 M142 W165 C172 F176
BS05	CLR	R	W228 N232	W163 N167
BS06	CLR	R	L248 L256	L183 L191
BS07	CLR	R	Y168 H173	Y103 H108

Gene Ontology

	Molecular Function
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G protein-coupled receptor activity
GO:0004979	beta-endorphin receptor activity
GO:0004985	G protein-coupled opioid receptor activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0031681	G-protein beta-subunit binding
GO:0038047	morphine receptor activity
GO:0042923	neuropeptide binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007197	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007600	sensory perception
GO:0008285	negative regulation of cell population proliferation
GO:0019233	sensory perception of pain
GO:0038003	G protein-coupled opioid receptor signaling pathway
GO:0048149	behavioral response to ethanol
GO:0050769	positive regulation of neurogenesis
GO:0061358	negative regulation of Wnt protein secretion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070588	calcium ion transmembrane transport
GO:0071315	cellular response to morphine
GO:0080135	regulation of cellular response to stress
GO:2000310	regulation of NMDA receptor activity

	Cellular Component
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043204	perikaryon
GO:0045202	synapse

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8efl, PDBe:8efl, PDBj:8efl
PDBsum	8efl
PubMed	36368306
UniProt	P35372\|OPRM_HUMAN Mu-type opioid receptor (Gene Name=OPRM1)

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