Structure of PDB 8e3x Chain R

Receptor sequence

>8e3xR (length=362) Species: 9606 (Homo sapiens) [Search protein sequence]

DCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMV
LVSCPELFRIFNPDVSRNCTEDGWSEPFPHYFDACGFDEQDYYYLSVKAL
YTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIK
DWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLV
ETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALW
WVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTL
LLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGE
VQAEIKRKWRSW

3D structure

PDB

8e3x Understanding VPAC receptor family peptide binding and selectivity

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	R	K28 Q31 N60 F81 I83 F84 F136 D147 Y150 Y157 Y161 R199 K206 Y211 F220 F233 V237 Y241 D298 M299 N300 W306 E374 R381 L382 E385 L386	K5 Q8 N37 F58 I60 F61 F87 D91 Y94 Y101 Y105 R143 K150 Y155 F164 F177 V181 Y185 D242 M243 N244 W250 E318 R325 L326 E329 L330

Gene Ontology

	Molecular Function
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G protein-coupled receptor activity
GO:0004999	vasoactive intestinal polypeptide receptor activity

	Biological Process
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G protein-coupled receptor signaling pathway

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:8e3x, PDBe:8e3x, PDBj:8e3x
PDBsum	8e3x
PubMed	36385145
UniProt	P41586\|PACR_HUMAN Pituitary adenylate cyclase-activating polypeptide type I receptor (Gene Name=ADCYAP1R1)

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