Structure of PDB 8dwc Chain R

Receptor sequence
>8dwcR (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
CYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAAD
FLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTERCL
SVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAW
CQTSDFITVAWLIFLCVVLCGSSLVLLIRILCLTRLYVTILLTVLVFLLC
GLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSF
3D structure
PDB8dwc Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.
ChainR
Resolution2.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R Y99 P100 E157 C161 L240 W241 F250 H254 Y77 P78 E135 C139 L212 W213 F222 H226
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:1902349 response to chloroquine
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8dwc, PDBe:8dwc, PDBj:8dwc
PDBsum8dwc
PubMed36302898
UniProtQ96LB2|MRGX1_HUMAN Mas-related G-protein coupled receptor member X1 (Gene Name=MRGPRX1)

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