Structure of PDB 8cn9 Chain R

Receptor sequence
>8cn9R (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLTALELMVLNVPRLMT
QDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWY
LTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
3D structure
PDB8cn9 A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders
ChainR
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA R E210 D212 E215 D217 E220 E58 D60 E63 D65 E68
BS02 CA R D338 S339 G365 D181 S182 G208
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8cn9, PDBe:8cn9, PDBj:8cn9
PDBsum8cn9
PubMed39196196
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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