Structure of PDB 7yfe Chain R

Receptor sequence
>7yfeR (length=1255) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence]
SMILTQFGPFIESISGITDQSNDVFENAAKAFSMFTRSDVYKALDEIPFS
EDAMLPIPPTIYTKPSHDSYYYIDALNRVRRKTYQGPDDVYVPNCSIVEL
LEPHETLTSYGRLSEAIENRAKDGDSQARIATTYGRIAESQARQIKAPLE
KFVLALLVAEAGGSLYDPVLQKYDEIPGLSHNCPLWCFREICRHISGPLP
DRAPYLYLSAGVFWLMSPRMTSAIPPLLSDLVNLAILQQTAGLDPSLVRL
GVQICLHAAASSSYAWFILKTKSIFPQNTLHSMYESLEGGYCPNLEWLEP
RSDYKFMYMGAMPLSTKYARSAPSNDKKARELGEKYGLSSVVSELRRRTK
TYSKHDFTSVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQK
DWTGPIGEIRILKDTTSSIARYLYRTWYLAAARMAAQPRTWDPLFQAIMR
SQYVTARGGSGATLRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPF
SHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYH
MNLSTTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVI
MAAIHEGVASSSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMIQHLS
KLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETF
LTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGNTAGKVNSET
IQKMLELISKYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVG
KERANSSAEEPWPAILDQIMGIFFNGVHDGLQWQRWIRYSWALCCAFSRQ
RTGYLQYPMWSFVYWGLPLVKVFGSDPWIFSWYMPTGDLGMYSWISLIRP
LMTRWMVANGYVTDKCSPVFGNADYRKCFNELKLYQGYYMAQLPRNPKKS
GRAAPREVREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHNPPS
LFDVPHKWYQGAQEAATATREELAEMDETLMRARKHSYSSFSKLLEAYLL
VKWRMCEAREPSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQ
TLFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADAL
AGKIMLQDVNTVQLARVVNLAVPDTWMSLDFDTMFKHHVKLLPKDGRHLN
TDIPPRMGWLRAILRFLGAGMAMTATGVAVDIYLEDIHGGGRSLGQRFMT
WMRQE
3D structure
PDB7yfe In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
ChainR
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna R R526 S561 K566 K783 R797 R524 S559 K564 K781 R795
BS02 rna R R459 G460 S462 K490 S514 R518 I528 P530 G683 N807 R457 G458 S460 K488 S512 R516 I526 P528 G681 N805
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0032774 RNA biosynthetic process
Cellular Component
GO:0019013 viral nucleocapsid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yfe, PDBe:7yfe, PDBj:7yfe
PDBsum7yfe
PubMed36469786
UniProtC9E870

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