Structure of PDB 7xtc Chain R

Receptor sequence
>7xtcR (length=275) Species: 562,9606 [Search protein sequence]
EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLS
VAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISID
RYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDK
VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFP
KAATTLGIIVGAFTVCWLPFFLLSTARPFICCIPLWVERTFLWLGYANSL
INPFIYAFFNRDLRTTYRSLLQCQY
3D structure
PDB7xtc GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
ChainR
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8K3 R D162 V163 C166 S243 T244 F343 F344 S347 D83 V84 C87 S164 T165 F220 F221 S224
BS02 CLR R L88 W371 L9 W243
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0030594 neurotransmitter receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0006939 smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007623 circadian rhythm
GO:0008015 blood circulation
GO:0022900 electron transport chain
GO:0042310 vasoconstriction
GO:0098664 G protein-coupled serotonin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0032588 trans-Golgi network membrane
GO:0042597 periplasmic space
GO:0045202 synapse

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Cellular Component
External links
PDB RCSB:7xtc, PDBe:7xtc, PDBj:7xtc
PDBsum7xtc
PubMed35714614
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P34969

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